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Advil, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. However, when taken with Monoamine Oxidase Inhibitors (MAOIs), Advil can interact with the medication and cause adverse effects.

MAOIs are a class of antidepressants that work by blocking the breakdown of certain neurotransmitters, such as serotonin, dopamine, and norepinephrine. These medications are often used to treat depression, Parkinson's disease, and other conditions.

When taken with MAOIs, Advil can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by high levels of serotonin in the body. This can lead to symptoms such as confusion, agitation, fever, and muscle stiffness.

The interaction between Advil and MAOIs is thought to occur because both medications affect the body's serotonin levels. Advil can increase serotonin levels, while MAOIs inhibit its breakdown. This combination can lead to a buildup of serotonin in the body, causing the adverse effects mentioned above.

It is essential to note that the interaction between Advil and MAOIs is not unique to these specific medications. Many NSAIDs, including aspirin, naproxen, and indomethacin, can also interact with MAOIs.

To minimize the risk of adverse effects, it is recommended to consult with a healthcare professional before taking Advil with MAOIs. They can help determine the appropriate dosage and monitor the patient's condition closely.

Sources:

1. MedlinePlus: Monoamine Oxidase Inhibitors (MAOIs) [1]
2. Mayo Clinic: Serotonin syndrome [2]
3. DrugPatentWatch.com: Advil (Ibuprofen) Patent Expiration [3]
4. National Institute of Mental Health: Monoamine Oxidase Inhibitors (MAOIs) [4]
5. Healthline: Can You Take Ibuprofen with Antidepressants? [5]

References:

[1] MedlinePlus. (n.d.). Monoamine Oxidase Inhibitors (MAOIs). Retrieved from <https://medlineplus.gov/druginfo/medmaster/a682139.html>

[2] Mayo Clinic. (n.d.). Serotonin syndrome. Retrieved from <https://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/syc-20351446>

[3] DrugPatentWatch.com. (n.d.). Advil (Ibuprofen) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent/advil-ibuprofen-patent-expiration/>

[4] National Institute of Mental Health. (n.d.). Monoamine Oxidase Inhibitors (MAOIs). Retrieved from <https://www.nimh.nih.gov/health/topics/monoamine-oxidase-inhibitors-maonis/index.shtml>

[5] Healthline. (n.d.). Can You Take Ibuprofen with Antidepressants? Retrieved from <https://www.healthline.com/health/ibuprofen-antidepressants>