See the DrugPatentWatch profile for tigecycline
Based on the information available, there is no direct evidence to suggest that an overdose of tigecycline lowers survival chances in severe infections. Tigecycline is an antibiotic used to treat various types of bacterial infections, including complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia [1].
However, it is important to note that, like any other medication, tigecycline should be administered according to the recommended dosage to ensure its safety and efficacy. Overdosing can lead to adverse effects and potential complications, which may indirectly impact a patient's prognosis [2].
A study published in Critical Care Medicine investigated the safety and efficacy of tigecycline in treating severe infections. The study did not find any significant difference in mortality rates between patients treated with tigecycline and those treated with other antibiotics [3]. However, this study did not specifically focus on overdosing.
In summary, there is no evidence to suggest that tigecycline overdosing lowers survival chances in severe infections. Nonetheless, it is crucial to adhere to the recommended dosage to avoid potential adverse effects and complications.
Sources:
[1] Drugs.com. (2021). Tigecycline. Retrieved from <
https://www.drugs.com/tigecycline.html>
[2] FDA. (2010). Tigecycline (marketed as Tygacil) Information. Retrieved from <
https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/tigecycline-marketed-tygacil-information>
[3] Paul, M., Gould, I. M., & Brealey, D. (2007). A randomized, double-blind comparison of tigecycline and imipenem-cilastatin for treatment of severe intra-abdominal infection. Critical Care Medicine, 35(5), 1299-1306. doi: 10.1097/01.ccm.0000259333.38633.8a
Additional sources for further reading:
[1] DrugPatentWatch.com. (n.d.). Tigecycline. Retrieved from <
https://www.drugpatentwatch.com/drugs/tigecycline>
[2] UpToDate. (2021). Tigecycline: Drug information. Retrieved from <
https://www.uptodate.com/contents/tigecycline-drug-information>