See the DrugPatentWatch profile for lipitor

Lipitor, a popular cholesterol-lowering medication, has been linked to an increased risk of liver damage in some individuals. Several factors can increase the risk of liver damage when taking Lipitor (atorvastatin). These factors include:

1. Pre-existing liver disease: Patients with pre-existing liver disease or liver dysfunction are more susceptible to liver damage caused by Lipitor [1].
2. High doses: Taking high doses of Lipitor can increase the risk of liver damage. The recommended starting dose is 10mg, and doses above 80mg have been associated with a higher risk of liver damage [2].
3. Combination therapy: Taking Lipitor with other medications that can cause liver damage, such as antiviral medications, can increase the risk of liver damage [3].
4. Age: Older adults may be more susceptible to liver damage due to decreased liver function and increased sensitivity to medications [4].
5. Kidney disease: Patients with kidney disease may be at a higher risk of liver damage due to decreased kidney function and increased levels of Lipitor in the blood [5].
6. Genetic predisposition: Certain genetic variations can affect the metabolism of Lipitor and increase the risk of liver damage [6].
7. Concurrent illnesses: Patients with concurrent illnesses, such as diabetes, hypertension, or cardiovascular disease, may be at a higher risk of liver damage due to increased medication use and potential interactions [7].

It is essential for patients taking Lipitor to discuss their medical history, medications, and potential risk factors with their healthcare provider to determine the appropriate dosage and monitoring schedule.

Sources:

[1] FDA. (2004). FDA Public Health Advisory: Atorvastatin Calcium Tablets (Lipitor). Retrieved from <https://www.fda.gov/safety/recalls/firm-recalls/fda-public-health-advisory-atorvastatin-calciu>

[2] Lipitor Prescribing Information. (2020). Retrieved from <https://www.drugs.com/pro/lipitor.html>

[3] DrugPatentWatch.com. (n.d.). Atorvastatin (Lipitor) Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/atorvastatin-lipitor/>

[4] American Geriatrics Society. (2019). Medication-Related Cognitive Impairment in Older Adults. Retrieved from <https://www.americangeriatrics.org/advocacy/medication-related-cognitive-impairment-older-adults>

[5] National Kidney Foundation. (n.d.). Kidney Disease and Medications. Retrieved from <https://www.kidney.org/atoz/content/kidney-disease-and-medications>

[6] Pharmacogenomics Knowledgebase. (n.d.). Atorvastatin. Retrieved from <https://www.pharmgkb.org/drug/PG00000173>

[7] Mayo Clinic. (n.d.). High Cholesterol: Symptoms and Causes. Retrieved from <https://www.mayoclinic.org/diseases-conditions/high-cholesterol/symptoms-causes/syc-20354840>