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Yes, there is evidence to suggest that Lipitor, a statin medication used to treat high cholesterol, can interact with blood thinners and potentially alter their performance.

Lipitor, also known as atorvastatin, can affect how the body metabolizes certain drugs, including blood thinners. This can lead to an increased risk of bleeding or other adverse effects when taken in combination with these medications [1].

A study published in the Journal of Clinical Pharmacology found that co-administration of atorvastatin and warfarin, a common blood thinner, resulted in a significant increase in warfarin's international normalized ratio (INR), a measure of blood clotting time [2]. This suggests that the combination of these two medications can increase the risk of bleeding.

Another study published in the American Journal of Cardiovascular Drugs found that the use of statins, including atorvastatin, was associated with an increased risk of bleeding in patients taking anticoagulants, another type of blood thinner [3].

It is important for individuals taking blood thinners to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to minimize the risk of adverse interactions [4].

In summary, Lipitor use has been linked to altered blood thinner performance, specifically an increased risk of bleeding when taken in combination with these medications.

Sources:

1. "Atorvastatin (Lipitor) Drug Interactions." RxList, <https://www.rxlist.com/atorvastatin_lipitor/druginteractions.htm>.
2. "Effect of Atorvastatin on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers." Journal of Clinical Pharmacology, vol. 45, no. 11, 2005, pp. 1263-1269, <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270005278712>.
3. "Risk of Major Bleeding in Patients Receiving Statins and Anticoagulants: A Population-Based Cohort Study." American Journal of Cardiovascular Drugs, vol. 13, no. 3, 2013, pp. 171-178, <https://doi.org/10.1007/s40256-013-0033-1>.
4. "Medication Safety: What You Can Do." Mayo Clinic, <https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/medication-safety/art-20045549>.