See the DrugPatentWatch profile for vascepa

Vascepa (icosapent ethyl) is a prescription medication used to lower triglyceride levels in adults. According to the drug label, Vascepa should be taken with food [1]. However, there is no specific information available on whether Vascepa can be taken with high-fat foods.

A recent study published in the Journal of Clinical Lipidology investigated the effects of high-fat meals on the pharmacokinetics of icosapent ethyl in healthy adults [2]. The study found that taking icosapent ethyl with a high-fat meal did not significantly affect its absorption or metabolism. However, the study only investigated the effects of a single high-fat meal, and it is unclear whether these findings apply to chronic high-fat intake.

Another study published in the American Journal of Cardiovascular Drugs investigated the effects of icosapent ethyl on lipid levels in patients with hypertriglyceridemia who consumed a high-fat meal [3]. The study found that icosapent ethyl significantly reduced triglyceride levels in patients who consumed a high-fat meal, suggesting that it may be effective even in the presence of high-fat intake.

Overall, there is limited information available on whether Vascepa can be taken with high-fat foods. While one study suggests that taking Vascepa with a high-fat meal does not significantly affect its absorption or metabolism, more research is needed to determine the effects of chronic high-fat intake on the medication's efficacy.

Sources:
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202057s023lbl.pdf
[2] https://pubmed.ncbi.nlm.nih.gov/34458694/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379293/