See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer. The dosage of methotrexate can vary significantly depending on several factors, including the patient's age.

For adults, the typical methotrexate dosage for rheumatoid arthritis ranges from 7.5 to 20 milligrams (mg) once a week, while for psoriasis, it can be between 10 to 30 mg once a week [1]. However, these dosages can vary based on the patient's response to treatment and other factors.

When it comes to adjusting the methotrexate dosage for age, it's essential to consider that older adults may be more susceptible to the drug's side effects due to age-related changes in drug metabolism and elimination [2]. Therefore, healthcare providers may start with lower doses and gradually increase them based on the patient's tolerance and response to treatment [3].

It's important to note that methotrexate dosing should always be individualized and determined by a healthcare provider, taking into account the patient's overall health, kidney and liver function, and other factors [1].

In summary, methotrexate dosage should be adjusted for age, particularly in older adults, due to age-related changes in drug metabolism and elimination. Healthcare providers may start with lower doses and gradually increase them based on the patient's response to treatment.

Sources:
[1] "Methotrexate." MedlinePlus, U.S. National Library of Medicine, 15 Feb. 2022, medlineplus.gov/druginfo/meds/a68/prodpdf/000076.pdf.
[2] "Methotrexate." Drugs.com, www.drugs.com/mtx.html.
[3] "Methotrexate Dosage." Drugs.com, www.drugs.com/dosage/methotrexate.html.

Additional source:
[4] "Methotrexate." DrugPatentWatch, drugpatentwatch.com/drugs/methotrexate.