See the DrugPatentWatch profile for methotrexate
Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. However, its use can be complicated by interactions with other drugs. Here are some drugs that can interact harmfully with methotrexate:
1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Regular use of NSAIDs like ibuprofen, naproxen, and celecoxib can increase the risk of kidney damage when taken with methotrexate [1][2].
2. Aspirin: High doses of aspirin can increase methotrexate levels in the body, leading to toxicity [1].
3. Probenecid: This drug, used to treat gout, can increase methotrexate levels in the body, leading to toxicity [1].
4. Penicillin: This antibiotic can reduce the effectiveness of methotrexate [1].
5. Phenytoin: This anti-seizure medication can increase methotrexate levels in the body, leading to toxicity [1].
6. Leucovorin: While this drug is often used to reduce methotrexate toxicity, it can also increase methotrexate levels in the body if not dosed properly [1].
7. Theophylline: This drug, used to treat asthma and other respiratory conditions, can increase methotrexate levels in the body, leading to toxicity [1].
8. Trimethoprim/Sulfamethoxazole: This antibiotic can increase methotrexate levels in the body, leading to toxicity [1].
9. Azathioprine: This immunosuppressive drug can increase the risk of methotrexate toxicity [1].
10. Sulfasalazine: This drug, used to treat ulcerative colitis and rheumatoid arthritis, can increase methotrexate levels in the body, leading to toxicity [1].
It's important to note that this list is not exhaustive and other drugs may interact with methotrexate. Always consult with a healthcare provider or pharmacist before starting or stopping any medications [1].
Sources:
[1] "Methotrexate Drug Interactions." Drugs.com, www.drugs.com/drug-interactions/methotrexate,mdcid=1105.
[2] "Methotrexate Interactions." DrugPatentWatch.com, www.drugpatentwatch.com/drugs/methotrexate/interactions.