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Combining Advil (ibuprofen) and antidepressants could potentially lead to several harmful interactions. While both medications can be used safely on their own, their combined use may result in increased risk of certain side effects.

Advil, a non-prescription nonsteroidal anti-inflammatory drug (NSAID), can increase the risk of stomach ulcers and bleeding when taken with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [1]. This is due to the increased levels of serotonin in the body, which can affect the gastrointestinal system and lead to bleeding.

Additionally, combining Advil with monoamine oxidase inhibitors (MAOIs), a type of antidepressant, can result in a serious condition called serotonin syndrome [1]. Symptoms of serotonin syndrome include rapid heart rate, high blood pressure, agitation, confusion, and in severe cases, seizures and loss of consciousness.

It is important to consult a healthcare professional before combining any medications, including over-the-counter drugs like Advil, with antidepressants. They will be able to evaluate the potential risks and benefits and determine the safest course of treatment.

Sources:

1. DrugPatentWatch.com. (n.d.). Advil and Antidepressants Interactions. Retrieved from <https://www.drugpatentwatch.com/interactions/advil-and-antidepressants>