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Oranges and the medication Lipitor, a statin used to treat high cholesterol, can interact in a way that may affect the drug's efficacy. Grapefruit is more commonly known for its interactions with Lipitor and other statins, but oranges can have a similar, yet less severe, effect [1].

Oranges contain furanocoumarins, which can inhibit the CYP3A4 enzyme in the small intestine [1]. This enzyme is responsible for metabolizing Lipitor (atorvastatin) and other statins [2]. When the CYP3A4 enzyme is inhibited, the absorption of Lipitor increases, potentially leading to higher concentrations of the drug in the bloodstream [1].

While this interaction is not typically dangerous, it may increase the risk of side effects such as muscle pain, liver damage, and kidney damage [1]. Patients taking Lipitor should consult their healthcare provider or pharmacist before consuming large quantities of oranges or orange juice [1].

It is important to note that, although oranges can interact with Lipitor, the interaction is generally weaker than that of grapefruit [1]. Grapefruit contains higher levels of furanocoumarins, which more significantly inhibit the CYP3A4 enzyme [1].

In summary, oranges can interact with Lipitor by inhibiting the CYP3A4 enzyme, leading to increased absorption and potential side effects [1]. Patients should consult their healthcare provider or pharmacist before consuming large quantities of oranges or orange juice while taking Lipitor [1].

Sources:
[1] DrugPatentWatch.com. (n.d.). Orange and Lipitor (Atorvastatin) Interaction. Retrieved from https://www.drugpatentwatch.com/interactions/orange-and-lipitor-atorvastatin
[2] Flockhart, D. A. (2007). Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine. Retrieved from https://www.ibh.org/pdf/p450.pdf