See the DrugPatentWatch profile for tigecycline

Proper storage is crucial for maintaining the potency of tigecycline, a last-resort antibiotic used to treat severe bacterial infections. Tigecycline is a sensitive compound that can be significantly affected by storage conditions.

Tigecycline, like many other antibiotics, is susceptible to degradation when exposed to heat, light, and moisture. Therefore, it is recommended to store tigecycline at controlled room temperature, between 20-25°C (68-77°F) [1]. Excursions are permitted between 15-30°C (59-86°F) [1]. It is essential to avoid exposing the drug to extreme temperatures, such as direct sunlight or freezing conditions, as these can compromise its stability and potency.

Furthermore, tigecycline should be protected from moisture. The drug should be stored in a tightly closed container to prevent any potential degradation caused by humidity [1]. It is also recommended to store the drug in its original packaging to protect it from light.

Proper storage of tigecycline is not only crucial for maintaining its potency but also for ensuring patient safety. Using a compromised drug can lead to treatment failure, increased risk of adverse effects, and development of antibiotic resistance [2].

In conclusion, storing tigecycline at controlled room temperature, away from light and moisture, is essential for maintaining its potency and ensuring its safe and effective use.

Sources:
[1] Tigecycline [package insert]. Pfizer Labs; 2017. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021827s021lbl.pdf>.
[2] Centers for Disease Control and Prevention. (2021, March 16). Antibiotic/Antimicrobial Resistance. Centers for Disease Control and Prevention. <https://www.cdc.gov/drugresistance/index.html>.