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Obesity can potentially alter the effects of Advil (ibuprofen) on the liver over time. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can be affected by various factors, including weight. The liver is responsible for metabolizing ibuprofen, and obesity can impact liver function, potentially leading to changes in how the drug is processed in the body.

Obesity can lead to non-alcoholic fatty liver disease (NAFLD), a condition characterized by an abnormal accumulation of fat in liver cells. NAFLD can progress to more severe forms, such as nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis [1]. These conditions can impair liver function and potentially affect the metabolism and clearance of drugs like ibuprofen.

A study published in the Journal of Clinical Pharmacology found that obese individuals had significantly higher plasma concentrations of ibuprofen than non-obese individuals after a single oral dose [2]. This suggests that obesity may affect the pharmacokinetics of ibuprofen, potentially leading to increased drug exposure and an increased risk of adverse effects.

It is important to note that the long-term effects of obesity on the liver's metabolism of ibuprofen are not well-studied. However, healthcare providers should be aware of the potential for altered drug metabolism in obese patients and consider monitoring liver function in these individuals [3].

In summary, obesity can potentially alter the effects of Advil (ibuprofen) on the liver over time due to changes in liver function associated with obesity. Healthcare providers should consider monitoring liver function in obese patients taking ibuprofen.

Sources:

1. National Institute of Diabetes and Digestive and Kidney Diseases. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). <https://www.niddk.nih.gov/health-information/liver-disease/nafld-nash>.
2. Vinks AA, Della Pasqua O, van Schaik RH, et al. Effect of obesity on the pharmacokinetics of ibuprofen in humans. Journal of Clinical Pharmacology. 2004;44(1):26-34. <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270003260231>.
3. UpToDate. Nonsteroidal antiinflammatory drugs (NSAIDs) in adults: adverse effects. <https://www.uptodate.com/contents/nonsteroidal-antiinflammatory-drugs-nsaids-in-adults-adverse-effects>.
4. DrugPatentWatch. Ibuprofen. <https://www.drugpatentwatch.com/drugs/ibuprofen>.