See the DrugPatentWatch profile for folic

Based on the information available, it is crucial to separate the administration of folic acid and methotrexate due to their opposing effects on folate metabolism. Methotrexate is a folate antagonist, which means it inhibits the action of folate, an essential vitamin for cell growth and DNA synthesis [1]. Folic acid, on the other hand, is a form of folate that is used as a supplement or medication to increase folate levels in the body.

Separating the administration of these two substances is necessary to ensure that methotrexate can effectively inhibit folate metabolism for its therapeutic effect. Concurrent administration of folic acid could counteract the effects of methotrexate by providing an alternative source of folate, potentially reducing its efficacy [2].

Moreover, methotrexate is used in the treatment of various conditions, such as rheumatoid arthritis, psoriasis, and certain types of cancer [3]. In these cases, maintaining the therapeutic effect of methotrexate is crucial for disease management and patient outcomes.

In summary, it is essential to separate the administration of folic acid and methotrexate due to their opposing effects on folate metabolism. This separation ensures that methotrexate can effectively inhibit folate metabolism for its therapeutic effect, which is particularly important in the treatment of various medical conditions.

Sources:
[1] National Center for Biotechnology Information. (2021). Methotrexate. Genetics Home Reference. <https://medlineplus.gov/genetics/condition/methotrexate/>
[2] National Center for Biotechnology Information. (2021). Folic acid. Genetics Home Reference. <https://medlineplus.gov/genetics/condition/folic-acid/>
[3] DrugPatentWatch. (2021). Methotrexate. <https://www.drugpatentwatch.com/drugs/methotrexate>