See the DrugPatentWatch profile for tigecycline

Based on the information provided, there is no direct biochemical reaction involving tigecycline and transaminases. However, transaminases are often mentioned in the context of tigecycline due to their potential involvement in drug metabolism. Tigecycline is a broad-spectrum antibiotic, and its metabolism involves various enzymes, including cytochrome P450 isoenzymes, but not specifically transaminases [1].

Transaminases are a class of enzymes that play a crucial role in amino acid metabolism. They catalyze the transfer of an amino group from a donor molecule to an acceptor molecule, which is usually an alpha-keto acid [2]. While tigecycline metabolism does not directly involve transaminases, changes in transaminase levels have been observed in patients receiving tigecycline treatment [3]. These changes are not attributed to a direct biochemical reaction but are instead thought to be a secondary effect of the drug or a result of the patient's condition.

In summary, there are no known biochemical reactions involving both tigecycline and transaminases. Tigecycline's metabolism primarily involves cytochrome P450 isoenzymes, not transaminases. However, transaminase levels may change during tigecycline treatment due to secondary effects or patient conditions [1, 2, 3].

Sources:
[1] DrugPatentWatch.com - Tigecycline
[2] National Center for Biotechnology Information - Transaminases
[3] National Library of Medicine - Tigecycline