See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various types of bacterial infections. However, it has been associated with an increased risk of liver injury in older patients [1]. As such, certain precautions should be taken when prescribing and administering this medication to this demographic.

First and foremost, healthcare providers should closely monitor liver function in older patients receiving tigecycline. This can be done through regular blood tests to assess liver enzyme levels [1]. If elevated levels are detected, it may be necessary to adjust the dosage or consider alternative antibiotic therapies.

Additionally, older patients with pre-existing liver disease or other risk factors for liver injury should be closely monitored and may require more frequent liver function tests [1]. It is essential to balance the potential benefits of tigecycline treatment against the risk of liver injury in these patients.

Healthcare providers should also be aware of the potential for drug interactions that may increase the risk of liver injury. For example, concomitant use of tigecycline with other medications that are metabolized by the liver may increase the risk of liver toxicity [1]. Therefore, it is crucial to review a patient's medication regimen before initiating tigecycline therapy.

Furthermore, patients themselves should be educated on the signs and symptoms of liver injury, such as jaundice, dark urine, and abdominal pain [1]. They should be advised to seek medical attention promptly if they experience any of these symptoms.

In summary, tigecycline should be used with caution in older patients due to the increased risk of liver injury. Healthcare providers should closely monitor liver function, be aware of potential drug interactions, and educate patients on the signs and symptoms of liver injury.

Sources:
[1] DrugPatentWatch.com. (n.d.). Tigecycline: Liver Injury in Older Patients. Retrieved from <https://www.drugpatentwatch.com/drugs/tigecycline/liver-injury-in-older-patients>.