See the DrugPatentWatch profile for methotrexate

Methotrexate is a powerful medication used to treat various conditions, including rheumatoid arthritis, psoriasis, and cancer. While it is effective in managing symptoms, it can also have side effects and interact with other substances. Herbal supplements, in particular, can pose a risk when taken with methotrexate. Here are some specific herbal supplements to avoid or approach with caution:

1. St. John's Wort (Hypericum perforatum): This herb is known for its antidepressant properties, but it can interact with methotrexate by reducing its effectiveness and increasing the risk of toxicity. [1]
2. Ginkgo biloba: Ginkgo biloba may increase the risk of bleeding when taken with methotrexate, as both substances can thin the blood. [2]
3. Garlic (Allium sativum): Garlic may increase the risk of bleeding and interact with methotrexate, which can increase the risk of bleeding and bruising. [3]
4. Ginger (Zingiber officinale): While ginger is generally considered safe, it may interact with methotrexate and increase the risk of bleeding. [4]
5. Turmeric (Curcuma longa): Turmeric contains curcumin, which may interact with methotrexate and reduce its effectiveness. [5]
6. Valerian root (Valeriana officinalis): Valerian root may interact with methotrexate and increase the risk of drowsiness and dizziness. [6]

It is essential to consult with a healthcare provider before taking any herbal supplements, especially when taking methotrexate. They can help you make informed decisions and ensure your safety.

Sources:

[1] National Institutes of Health. (2020). St. John's Wort. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK92755/>

[2] Memorial Sloan Kettering Cancer Center. (2020). Ginkgo Biloba. Retrieved from <https://www.mskcc.org/cancer-care/integrative-medicine/complementary-therapies/herbs/ginkgo-biloba>

[3] University of Maryland Medical Center. (2020). Garlic. Retrieved from <https://www.umm.edu/health/medical/altmed/herbals/garlic>

[4] National Center for Complementary and Integrative Health. (2020). Ginger. Retrieved from <https://www.nccih.nih.gov/health/ginger>

[5] University of Maryland Medical Center. (2020). Turmeric. Retrieved from <https://www.umm.edu/health/medical/altmed/herbals/turmeric>

[6] National Institutes of Health. (2020). Valerian. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK92756/>

Note: DrugPatentWatch.com was not included as a source in this response, as it is primarily a database of pharmaceutical patents and does not provide information on herbal supplements and methotrexate interactions.