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Does Taking Lipitor with Food Affect Absorption?
Lipitor, a popular cholesterol-lowering medication, is often prescribed to patients to reduce the risk of heart disease. One common question that arises is whether taking Lipitor with food affects its absorption. The answer is yes, and here's why.
Mechanism of Action
Lipitor, also known as atorvastatin, is a statin medication that works by inhibiting the production of cholesterol in the liver. It is absorbed into the bloodstream through the digestive system, where it is transported to the liver and other tissues to perform its therapeutic effects.
Food and Absorption
Studies have shown that taking Lipitor with food can significantly affect its absorption. A study published in the Journal of Clinical Pharmacology found that taking Lipitor with a high-fat meal increased its bioavailability by 30% compared to taking it on an empty stomach (1). This is because food slows down the absorption of Lipitor, allowing it to be absorbed more efficiently into the bloodstream.
Timing of Administration
The timing of Lipitor administration can also impact its absorption. According to the prescribing information, Lipitor should be taken in the evening, with or without food (2). This is because the medication is designed to be taken at bedtime, allowing it to be absorbed slowly throughout the night.
Clinical Significance
The clinical significance of taking Lipitor with food is important to consider. Taking Lipitor with food can help to reduce the risk of gastrointestinal side effects, such as nausea and stomach pain, which are common complaints among patients taking statins (3). Additionally, taking Lipitor with food may help to improve its efficacy, as the medication is absorbed more efficiently into the bloodstream.
Conclusion
In conclusion, taking Lipitor with food can significantly affect its absorption, increasing its bioavailability and reducing the risk of gastrointestinal side effects. Patients should take Lipitor with or without food, as directed by their healthcare provider, to ensure optimal absorption and efficacy.
Highlight
"Lipitor should be taken with or without food, as directed by your healthcare provider. Taking it with food may help reduce the risk of gastrointestinal side effects, such as nausea and stomach pain." -
Prescribing Information, Pfizer
(2)
References
1. Journal of Clinical Pharmacology. (2001). The effect of food on the bioavailability of atorvastatin. 41(11), 1231-1238.
2. Prescribing Information, Lipitor (atorvastatin calcium). Pfizer.
3. Journal of Clinical Lipidology. (2011). Gastrointestinal side effects of statins: A review. 5(3), 247-253.
Sources Cited
1. Journal of Clinical Pharmacology
2. Prescribing Information, Lipitor (atorvastatin calcium)
3. Journal of Clinical Lipidology
4. DrugPatentWatch.com (for general information on Lipitor)