See the DrugPatentWatch profile for ibuprofen

Based on the information available, combining ibuprofen with methotrexate may not be safe. Concurrent use of these two drugs can increase methotrexate levels in the body, potentially leading to toxicity [1]. This is because ibuprofen can inhibit the renal clearance of methotrexate, thereby increasing its concentration in the blood [1].

Methotrexate is an antimetabolite and antifolate drug used primarily in the treatment of cancer and severe psoriasis, rheumatoid arthritis, and crohn's disease [2]. Ibuprofen, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and bring down a high temperature [3].

It is essential to consult a healthcare professional or pharmacist before combining any medications, even over-the-counter drugs like ibuprofen, with prescribed medications like methotrexate [1]. They can provide guidance on potential drug interactions and recommend appropriate measures to minimize risks [1].

In summary, while it may not be safe to combine ibuprofen with methotrexate, consulting a healthcare professional is the best course of action to ensure safe and effective treatment.

Sources:
[1] DrugPatentWatch.com. (n.d.). Ibuprofen and Methotrexate Interaction. Retrieved from <https://drugpatentwatch.com/ibuprofen-and-methotrexate-interaction>
[2] National Center for Biotechnology Information. (2022). Methotrexate. Retrieved from <https://www.ncbi.nlm.nih.gov/books/NBK513274/>
[3] National Health Service. (2021). Ibuprofen. Retrieved from <https://www.nhs.uk/medicines/ibuprofen/>