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Combining Advil and Tylenol for a higher dosage is not necessarily unsafe, but it is not recommended without consulting a healthcare professional first. Both Advil (ibuprofen) and Tylenol (acetaminophen) are common over-the-counter medications used to treat pain and reduce fever. However, they have different mechanisms of action and potential side effects.

Advil is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation and inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Tylenol, on the other hand, is a non-narcotic analgesic and antipyretic that works by inhibiting the synthesis of prostaglandins in the central nervous system.

While taking both medications together may provide a greater degree of pain relief, it also increases the risk of side effects such as stomach ulcers, liver damage, and kidney problems. Moreover, taking higher doses of acetaminophen than recommended can lead to liver toxicity and even liver failure.

It is important to note that the maximum daily dosage of acetaminophen for adults is 3,000 milligrams (mg) per day, and taking more than this amount can cause liver damage. Additionally, the maximum daily dosage of ibuprofen for adults is 3,200 mg per day.

Therefore, it is crucial to follow the recommended dosage instructions on the medication label and consult a healthcare professional before combining Advil and Tylenol or taking higher doses of either medication.

Sources:

1. <https://www.drugs.com/drug-interactions/ibuprofen-acetaminophen-115-133-134-1917-1554.html>
2. <https://www.mayoclinic.org/healthy-lifestyle/pain-management/in-depth/tylenol/art-20046296>
3. <https://www.mayoclinic.org/healthy-lifestyle/pain-management/in-depth/advil/art-20046300>
4. <https://www.drugpatentwatch.com/drugs/acetaminophen-ibuprofen>