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Chewable Advil, also known as Ibuprofen, is a common over-the-counter medication used to relieve pain, reduce fever, and inflammation. While it is generally considered safe for most people, taking chewable Advil on an empty stomach can lead to several side effects.

One potential side effect of taking chewable Advil on an empty stomach is gastrointestinal irritation [1]. This can include symptoms such as stomach pain, nausea, and vomiting. Ibuprofen can also cause stomach ulcers and bleeding, and taking it on an empty stomach may increase the risk of these complications [1].

Additionally, taking chewable Advil on an empty stomach may increase the absorption rate of the medication, leading to higher levels of ibuprofen in the bloodstream [2]. This can increase the risk of side effects such as headache, dizziness, and ringing in the ears [1].

It is important to follow the instructions on the label of chewable Advil and not exceed the recommended dosage. If you experience any side effects after taking chewable Advil, it is recommended to speak with a healthcare provider [1].

In summary, taking chewable Advil on an empty stomach can lead to gastrointestinal irritation, increased absorption rate, and higher levels of ibuprofen in the bloodstream. It is important to follow the instructions on the label and speak with a healthcare provider if any side effects are experienced.

Sources:
[1] Mayo Clinic. (2021). Ibuprofen (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20069696?p=1>
[2] DrugPatentWatch. (2021). Ibuprofen. Retrieved from <https://www.drugpatentwatch.com/drugs/ibuprofen>