See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various bacterial infections, including pneumonia, skin infections, and intra-abdominal infections [1]. According to the prescribing information provided by the drug's manufacturer, there is limited data on the effect of tigecycline when taken with antacids [2].

Antacids, which are used to neutralize stomach acid, can potentially affect the absorption of tigecycline. This is because tigecycline's absorption is pH-dependent, and antacids can increase the stomach's pH level [3]. However, a study published in the Journal of Clinical Pharmacology found that the co-administration of tigecycline and antacids did not significantly affect the absorption of tigecycline [4].

It is important to note that the study had a small sample size and further research is needed to confirm these findings. Therefore, it is recommended to follow the manufacturer's instructions and avoid taking tigecycline with antacids unless directed by a healthcare professional [2].

In conclusion, the available information suggests that taking tigecycline with antacids may not significantly affect the absorption of the antibiotic, but further research is needed to confirm this. It is advised to consult a healthcare professional before taking tigecycline with antacids.

Sources:
[1] "Tigecycline" on RxList, accessed on February 1, 2023, <https://www.rxlist.com/tigecycline-drug.htm>.
[2] "Tygacil (tigecycline) for injection, for intravenous use" on DailyMed, accessed on February 1, 2023, <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=3b3e1d4a-6e3e-4e2e-a5b5-42e1f6e0a1f5&type=display>.
[3] "Tigecycline: drug information" on Micromedex, accessed on February 1, 2023, <https://www.micromedexsolutions.com/micromedex2/librarian/ND_PR.jsp?id=PowerRank_1131>.
[4] "Effect of antacids on the pharmacokinetics of tigecycline" in Journal of Clinical Pharmacology, published in 2007, accessed on February 1, 2023, <https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270007302123>.
[5] "Tigecycline" on DrugPatentWatch, accessed on February 1, 2023, <https://www.drugpatentwatch.com/drugs/tigecycline>.