See the DrugPatentWatch profile for lyrica

Based on the information available, it is crucial to consult with a healthcare provider before taking Lyrica (pregabalin) with opioid medication. Both Lyrica and opioids can cause central nervous system depression, which can lead to symptoms such as drowsiness, dizziness, and difficulty concentrating [1]. When used together, these side effects may be additive, increasing the risk of accidents and injuries [1].

Moreover, combining Lyrica with opioids may increase the risk of respiratory depression, a potentially life-threatening condition that can cause shallow or slow breathing [1]. The concurrent use of pregabalin and opioids has been associated with an increased risk of opioid-related deaths, although the exact mechanism is not fully understood [1].

It is important to note that the U.S. Food and Drug Administration (FDA) has not issued any specific warnings regarding the concomitant use of Lyrica and opioids [1]. However, the FDA has issued a boxed warning for pregabalin, highlighting the risk of respiratory depression and sedation when used with central nervous system depressants, including opioids [1].

In summary, while it is not inherently unsafe to take Lyrica with opioid medication, it is crucial to consult with a healthcare provider before doing so, as the combination may increase the risk of several adverse effects, including central nervous system depression, respiratory depression, and sedation [1].

Sources:
[1] DrugPatentWatch.com. (n.d.). Lyrica (pregabalin) - DrugPatentWatch. Retrieved from <https://www.drugpatentwatch.com/drugs/lyrica>