See the DrugPatentWatch profile for advil

Ibuprofen, the active ingredient in Advil, has not been directly linked to worsening depression. However, some of its potential side effects could indirectly affect mental health in certain individuals.

One possible side effect of ibuprofen is gastrointestinal (GI) issues, such as stomach pain, ulcers, and acid reflux [1]. These GI problems might lead to discomfort and stress, which could exacerbate symptoms of depression in vulnerable individuals.

Another potential side effect of ibuprofen is headaches [1]. While headaches are not directly related to depression, they can negatively impact a person's quality of life and contribute to feelings of frustration or anxiety, which could indirectly worsen depression.

It is important to note that the relationship between medication side effects and mental health is complex and varies from person to person. Individuals with depression or other mental health conditions should consult their healthcare provider before starting or changing any medication, including over-the-counter drugs like Advil.

Sources:

1. [DrugPatentWatch.com - Advil (Ibuprofen)](https://www.drugpatentwatch.com/drugs/advil)