See the DrugPatentWatch profile for methotrexate

Methotrexate is a powerful medication commonly used to treat various conditions, including rheumatoid arthritis, psoriasis, and cancer. While it is effective in managing symptoms, it can also cause a range of side effects, including nausea, vomiting, diarrhea, and mouth sores. However, some herbal supplements may interact with methotrexate, potentially worsening its side effects.

One of the primary concerns is the interaction between methotrexate and St. John's Wort (Hypericum perforatum). This herbal supplement is commonly used to treat mild depression and anxiety. However, it can significantly reduce the effectiveness of methotrexate by increasing its metabolism and elimination from the body [1]. This can lead to reduced efficacy of the medication and potentially worsen symptoms.

Another herbal supplement that may interact with methotrexate is Ginkgo biloba. While it is often used to improve memory and cognitive function, it can also increase the risk of bleeding, which is a known side effect of methotrexate [2]. This increased risk of bleeding can be particularly concerning for patients taking methotrexate for conditions such as cancer.

Feverfew (Tanacetum parthenium) is another herbal supplement that may interact with methotrexate. Feverfew is often used to treat headaches and migraines, but it can also increase the risk of bleeding and interact with methotrexate's antifolate properties [3].

It is essential for patients taking methotrexate to consult with their healthcare provider before using any herbal supplements. This is particularly important for patients taking methotrexate for conditions such as cancer, where the potential interactions can have serious consequences.

In conclusion, while herbal supplements may seem like a natural and harmless way to manage symptoms, they can potentially interact with methotrexate and worsen its side effects. Patients taking methotrexate should consult with their healthcare provider before using any herbal supplements to ensure safe and effective treatment.

Sources:

[1] DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/patent/US-6-165-444>

[2] National Cancer Institute. (n.d.). Ginkgo biloba. Retrieved from <https://www.cancer.gov/about-cancer/treatment/drugs/ginkgo-biloba>

[3] University of Maryland Medical Center. (n.d.). Feverfew. Retrieved from <https://www.umm.edu/health/medical/altmed/herb/feverfew>