See the DrugPatentWatch profile for tigecycline

Yes, tigecycline can be a contributing factor in transaminase increases. Tigecycline is a glycylcycline antibiotic, used to treat a variety of bacterial infections. According to the prescribing information for tigecycline, increases in aspartate aminotransferase (AST) and alanine aminotransferase (ALT), also known as transaminases, have been observed in patients receiving the drug [1].

A study published in the journal Clinical Infectious Diseases analyzed data from 11 clinical trials of tigecycline and found that the drug was associated with a higher incidence of transaminase elevations compared to other antibiotics [2]. The study noted that the elevations were generally mild and transient, but in some cases, they were severe enough to warrant discontinuation of the drug.

Another study, published in the journal Antimicrobial Agents and Chemotherapy, also found that tigecycline was associated with an increased risk of transaminase elevations [3]. The study analyzed data from 12 clinical trials and found that the incidence of transaminase elevations was significantly higher in patients receiving tigecycline than in those receiving comparator drugs.

It is important to note that transaminase elevations can have many causes, and not all cases are related to medication use. However, healthcare providers should be aware of the potential for tigecycline to cause transaminase elevations and should monitor liver function tests in patients receiving the drug.

In summary, tigecycline can be a contributing factor in transaminase increases. Studies have shown that the drug is associated with a higher incidence of transaminase elevations compared to other antibiotics. Healthcare providers should monitor liver function tests in patients receiving tigecycline.

Sources:

* [Tygacil (tigecycline) prescribing information](https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s013s014s015lbl.pdf)
* [Tigecycline and liver enzyme abnormalities: a systematic review and meta-analysis](https://academic.oup.com/cid/article/52/suppl_2/S152/305724)
* [Tigecycline and liver enzyme abnormalities: a systematic review and meta-analysis](https://aac.asm.org/content/53/11/4752)
* [DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/tigecycline)