See the DrugPatentWatch profile for aspirin

Enteric coating is a technology used in pharmaceutical manufacturing to control the release of a drug into the body [1]. This coating is particularly useful for drugs that can cause stomach irritation or ulcers when taken on an empty stomach, such as aspirin [1]. The enteric coating ensures that the drug is released in the small intestine instead of the stomach [1].

In the case of aspirin, enteric coating can influence the time of onset of action by delaying the release of the drug into the bloodstream [2]. Aspirin is typically absorbed in the stomach, and its effects are usually felt within 30 minutes of ingestion [2]. However, enteric-coated aspirin can take up to 45 minutes to an hour to start working [2].

The reason for this delay is that the enteric coating must first dissolve in the small intestine before the aspirin can be released [1]. This process takes longer than the direct absorption of aspirin in the stomach [2].

It's important to note that while enteric coating can delay the onset of action of aspirin, it can also provide other benefits, such as reducing stomach irritation and ulcers [1]. Therefore, the use of enteric-coated aspirin may be recommended for individuals who have a history of stomach problems or who are taking aspirin for long-term use [1].

In summary, enteric coating can influence the time of onset of action of aspirin by delaying its release into the bloodstream. While this can result in a slower onset of action, it can also provide other benefits, such as reducing stomach irritation and ulcers.

Sources:

1. "Enteric Coating: What Is It and How Does It Work?" Drugs.com, <https://www.drugs.com/article/enteric-coating.html>.
2. "How Long Does It Take for Aspirin to Work?" Healthline, <https://www.healthline.com/health/how-long-does-it-take-for-aspirin-to-work>.