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When combining Lipitor, a statin medication used to treat high cholesterol, with ACE (Angiotensin-Converting Enzyme) inhibitors, a class of drugs used to treat hypertension and heart failure, there are generally no serious side effects. In fact, these two types of medications are often used together to manage cardiovascular conditions [1].

However, combining these medications can increase the risk of certain side effects. For example, the combined use of Lipitor and ACE inhibitors may increase the risk of developing muscle pain or weakness, a condition known as myalgia or myopathy [1][2]. This side effect is also associated with the use of Lipitor monotherapy [1].

Additionally, the risk of developing rhabdomyolysis, a serious condition in which muscle tissue breaks down, releasing muscle fiber contents into the bloodstream, may be increased when combining Lipitor with ACE inhibitors [2]. However, this side effect is rare and typically only occurs in cases of high-dose Lipitor use or in patients with multiple underlying risk factors [2].

It is important to note that the risk of developing these side effects is generally low and that the benefits of combining Lipitor and ACE inhibitors often outweigh the potential risks [1]. Patients should consult with their healthcare provider to determine the most appropriate treatment plan for their individual needs.

Sources:
[1] "Lipitor (Atorvastatin) Drug Interactions." RxList, 2021, <https://www.rxlist.com/lipitor_atorvastatin/druginteractions.htm>.
[2] "Drug Interactions Between ACE Inhibitors and Statins." DrugPatentWatch, 2021, <https://www.drugpatentwatch.com/drug-interactions/ace-inhibitors-and-statins>.