See the DrugPatentWatch profile for ativan

Dosage plays a significant role in the development of tolerance to Ativan, a medication commonly prescribed for the treatment of anxiety disorders. Tolerance occurs when the body becomes accustomed to a drug, requiring increasingly larger doses to achieve the same effect [1].

Ativan, also known as lorazepam, is a benzodiazepine that works by enhancing the effect of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain [2]. When Ativan is taken consistently, the brain may adapt to the presence of the drug, reducing its effectiveness over time [1].

While increasing the dosage can temporarily restore the drug's effectiveness, this practice carries the risk of dependence, addiction, and severe side effects [3]. Moreover, higher doses do not necessarily translate to greater therapeutic benefits and may even lead to diminishing returns [1].

It is crucial to follow the prescribed dosage and consult a healthcare professional before making any changes to the dosage or treatment plan [2]. Monitoring and reporting any changes in the drug's effectiveness to the healthcare provider can help ensure the safe and effective use of Ativan [1].

In summary, while increasing the dosage of Ativan may temporarily counteract tolerance, it can lead to dependence, addiction, and severe side effects. It is essential to adhere to the prescribed dosage and consult a healthcare professional for any changes in the treatment plan.

Sources:

1. National Institute on Drug Abuse. (2020). Misuse of Prescription Drugs. <https://www.drugabuse.gov/publications/research-reports/misuse-prescription-drugs/introduction>
2. U.S. National Library of Medicine. (2021). Lorazepam. <https://medlineplus.gov/druginfo/meds/a682440.html>
3. DrugPatentWatch. (2021). Ativan (Lorazepam) Drug Profile. <https://www.drugpatentwatch.com/drugs/ativan>