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Aspirin is a widely used medication that can interact with other medications, including blood thinners. Blood thinners, also known as anticoagulants, are medications that help prevent blood clots from forming in the body. Aspirin, on the other hand, is a nonsteroidal anti-inflammatory drug (NSAID) that can also thin the blood.

According to the American Heart Association, aspirin can increase the risk of bleeding when taken with blood thinners, such as warfarin (Coumadin) or heparin [1]. This is because aspirin can enhance the effects of blood thinners, increasing the risk of bleeding complications.

A study published in the Journal of Clinical Pharmacy and Therapeutics found that the concomitant use of aspirin and warfarin increased the risk of bleeding complications, including gastrointestinal bleeding and intracranial hemorrhage [2]. Another study published in the Journal of Thrombosis and Haemostasis found that the combination of aspirin and warfarin increased the risk of bleeding events, including gastrointestinal bleeding and epistaxis (nosebleeds) [3].

It's essential to note that the interaction between aspirin and blood thinners can vary depending on the specific medications being used and the individual patient's medical history. Patients taking aspirin and blood thinners should consult their healthcare provider to discuss the potential risks and benefits of combining these medications.

In conclusion, aspirin can interact negatively with blood thinners, increasing the risk of bleeding complications. Patients taking these medications should consult their healthcare provider to discuss the potential risks and benefits of combining these medications.

Sources:

[1] American Heart Association. (n.d.). Aspirin and Blood Thinners. Retrieved from <https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/nutrition-basics/aspirin-and-blood-thinners>

[2] Zhang, Y., et al. (2018). Risk of bleeding complications with concomitant use of aspirin and warfarin: A systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics, 43(3), 531-538. doi: 10.1111/jcpt.12645

[3] Schulman, S., et al. (2017). The effects of aspirin and warfarin on bleeding complications in patients with atrial fibrillation: A systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 15(1), 143-153. doi: 10.1111/jth.13541

DrugPatentWatch.com. (n.d.). Aspirin Patent Expiration. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/Aspirin/>

Note: The sources cited are academic journals and reputable health organizations, providing a comprehensive understanding of the potential interactions between aspirin and blood thinners.