See the DrugPatentWatch profile for tigecycline

Tigecycline is an antibiotic used to treat various types of bacterial infections. According to the drug's prescribing information, it has been associated with a range of side effects related to liver function.

Firstly, tigecycline has been shown to increase liver enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), in some patients. These enzyme increases may indicate liver inflammation or damage [1].

Secondly, tigecycline has been linked to cases of drug-induced hepatitis, a condition characterized by inflammation of the liver. Symptoms of drug-induced hepatitis can include jaundice, fatigue, abdominal pain, and dark urine [1].

Lastly, tigecycline has been associated with cholestatic hepatitis, a rare but serious form of liver injury. Cholestatic hepatitis is characterized by reduced bile flow, leading to jaundice, itching, and dark urine [1].

It is important to note that not all patients taking tigecycline will experience liver-related side effects. However, healthcare providers should monitor liver function in patients receiving tigecycline, particularly those with pre-existing liver disease or those taking other medications known to affect liver function [1].

In summary, tigecycline has been associated with increased liver enzymes, drug-induced hepatitis, and cholestatic hepatitis. Healthcare providers should monitor liver function in patients taking tigecycline, particularly those with pre-existing liver disease or those taking other medications known to affect liver function.

Sources:
[1] Tigecycline (Tygacil) [Prescribing Information]. Pfizer Labs. 2018. Available from: <https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021927s023s024lbl.pdf>.