See the DrugPatentWatch profile for methotrexate

Yes, herbal supplements can interact with methotrexate. Methotrexate is a commonly prescribed drug used to treat various conditions, such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. When taking methotrexate, it is crucial to inform healthcare providers about any herbal supplements being used, as they can potentially interact with the drug and cause adverse effects [2].

Some herbal supplements can affect how methotrexate is metabolized in the body, leading to increased or decreased levels of the drug in the bloodstream [3]. For instance, St. John's Wort, a popular herbal supplement used for depression, can reduce methotrexate levels in the body, potentially decreasing its effectiveness [4]. Conversely, echinacea, another commonly used herbal supplement, may increase methotrexate levels, leading to a higher risk of toxicity [5].

It is essential to consult with healthcare professionals before starting or continuing the use of herbal supplements while on methotrexate therapy. Healthcare providers can offer guidance on potential interactions, help manage any adverse effects, and recommend alternative treatments if necessary [2][3].

In summary, methotrexate can interact with herbal supplements, which can result in decreased drug effectiveness or increased toxicity. Always consult healthcare professionals before combining methotrexate with herbal supplements.

Sources:

1. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062854>
2. National Institute on Aging. (2019). Herbal Supplements and Cancer Treatment. Retrieved from <https://www.nia.nih.gov/health/herbal-supplements-and-cancer-treatment>
3. American Cancer Society. (2019). Complementary and Alternative Methods and Cancer: Herbs and Dietary Supplements. Retrieved from <https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/herbs-vitamins-and-minerals/herbs>
4. University of Maryland Medical Center. (2019). Methotrexate Interactions. Retrieved from <https://www.umm.edu/health/medical/altmed/drug-interactions/methotrexate-interactions>
5. DrugPatentWatch. (2021). Methotrexate Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>