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To safely take Advil (ibuprofen) with antidepressants, it's crucial to consider several factors.

Firstly, Advil is a non-prescription medication used to treat pain, fever, and inflammation [1]. Antidepressants, on the other hand, are prescribed to manage depression and anxiety disorders [3].

Secondly, both Advil and antidepressants can be metabolized in the liver by an enzyme called cytochrome P450 [2][3]. This means they can interact, potentially leading to increased or decreased levels of one or both drugs in the body.

However, the severity of this interaction can vary depending on the specific type of antidepressant. For instance, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are less likely to interact with Advil than monoamine oxidase inhibitors (MAOIs) [2][3].

Despite this, it's essential to consult with a healthcare provider before combining these medications. They may adjust the dosage or recommend alternative treatments to minimize the risk of adverse effects [2][3].

In some cases, symptoms such as dizziness, drowsiness, or stomach upset may occur [2]. If these symptoms are severe or persist, it's crucial to seek medical attention immediately.

In conclusion, while it's possible to take Advil with antidepressants, it should be done under the supervision of a healthcare provider to ensure safety and efficacy.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.cam.ac.uk/research/discussion/antidepressants-and-pain-killers-should-we-be-worried
[3] https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/