See the DrugPatentWatch profile for methotrexate

When treating elderly patients with Methotrexate, a medication commonly used for inflammatory conditions like rheumatoid arthritis, doctors should take several precautions due to the increased risk of adverse effects in this population [1].

Firstly, doctors should closely monitor renal function, as Methotrexate is primarily excreted by the kidneys. Age-related declines in renal function can lead to increased drug accumulation and toxicity [1][2].

Secondly, liver function should be regularly assessed, as Methotrexate can cause hepatotoxicity. This risk is higher in the elderly due to age-related liver changes and potential for polypharmacy [1][2].

Thirdly, doctors should be aware of the increased risk of myelosuppression in elderly patients, which can lead to severe neutropenia, thrombocytopenia, and anemia. Regular complete blood counts are recommended [1][2].

Furthermore, doctors should consider the potential for drug interactions, particularly with medications that can increase Methotrexate levels or exacerbate its side effects. Regular medication reviews are crucial in the elderly population [1][2].

Lastly, doctors should ensure that elderly patients are well-informed about the potential side effects of Methotrexate, including gastrointestinal symptoms, alopecia, and photosensitivity. They should also be advised to avoid alcohol, as it can exacerbate liver toxicity [1][2].

Sources:
[1] "Methotrexate", Lexicomp®, Hudson, Ohio: Wolters Kluwer Health, Inc. [2022].
[2] "Methotrexate", DrugPatentWatch.com, accessed on [2022-03-01].