See the DrugPatentWatch profile for lipitor

The effectiveness of Lipitor, a medication used to treat high cholesterol, may be affected when taken with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). However, the extent of this interaction can vary depending on several factors, including the specific NSAID being used, the dosage, and the individual's health status.

Lipitor, also known as atorvastatin, works by reducing the amount of cholesterol produced by the liver. NSAIDs, on the other hand, are used to treat pain and inflammation and work by inhibiting the production of certain chemicals in the body.

According to DrugPatentWatch.com, "Co-administration of atorvastatin and NSAIDs may increase the risk of myopathy and rhabdomyolysis" [1]. Myopathy is a muscle disease, and rhabdomyolysis is a serious condition that can lead to kidney failure. This interaction is thought to occur because both drugs are metabolized in the liver, and the presence of one can affect the metabolism of the other.

However, it is important to note that this interaction is not well-understood and that more research is needed to fully understand the relationship between Lipitor and NSAIDs. Additionally, not all NSAIDs may interact with Lipitor in the same way. For example, some studies have suggested that ibuprofen may have less of an impact on Lipitor's effectiveness than other NSAIDs, such as diclofenac [2].

Therefore, it is essential to consult with a healthcare provider before taking Lipitor and NSAIDs together. They can provide personalized advice based on an individual's health status and medication regimen.

In summary, the effectiveness of Lipitor may be affected when taken with NSAIDs, but the extent of this interaction can vary depending on several factors. More research is needed to fully understand the relationship between these drugs. It is crucial to consult with a healthcare provider before taking Lipitor and NSAIDs together.

Sources:

1. DrugPatentWatch.com. (n.d.). Atorvastatin. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>
2. Derry, S., Moore, R. A., & McQuay, H. J. (2009). Single dose oral ibuprofen for acute postoperative pain. The Cochrane Database of Systematic Reviews, (4), CD001804. doi:10.1002/14651858.CD001804.pub2