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Can cosentyx cause cardiovascular side effects?

See the DrugPatentWatch profile for cosentyx

Can Cosentyx Cause Cardiovascular Side Effects?

Understanding the Risks of Biologics

Cosentyx, a biologic medication, has revolutionized the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, like all medications, it carries potential side effects, including cardiovascular risks. In this article, we'll delve into the possibility of Cosentyx causing cardiovascular side effects and explore the available data.

What is Cosentyx?

Cosentyx is a human interleukin-17A antagonist, marketed by Novartis, used to treat moderate to severe plaque psoriasis, psoriatic arthritis, and active ankylosing spondylitis. It works by blocking the activity of interleukin-17A, a protein that plays a key role in the inflammatory process.

Cardiovascular Risks: A Growing Concern

Cardiovascular disease is a leading cause of morbidity and mortality worldwide. Biologics, including Cosentyx, have been linked to an increased risk of cardiovascular events, such as heart attacks, strokes, and blood clots.

The Data: What Do We Know?

A study published in the Journal of Investigative Dermatology (1) analyzed the cardiovascular safety of Cosentyx in patients with psoriasis. The researchers found that the risk of major adverse cardiovascular events (MACE) was higher in patients receiving Cosentyx compared to those receiving placebo. However, the absolute risk was low, and the study concluded that the benefits of Cosentyx outweighed the risks.

A Closer Look at the Data

A review of the FDA's Adverse Event Reporting System (FAERS) database (2) revealed that Cosentyx was associated with a higher risk of cardiovascular events, including heart failure, arrhythmias, and hypertension. However, the database is limited by its reliance on voluntary reporting and may not capture all cases.

Expert Insights

Dr. Mark Lebwohl, a renowned dermatologist, emphasizes the importance of monitoring patients for cardiovascular risk factors, particularly in those with a history of cardiovascular disease (3). "While the risk of cardiovascular events with Cosentyx is low, it's essential to weigh the benefits against the risks and monitor patients closely."

The Role of Risk Factors

Several risk factors can increase the likelihood of cardiovascular side effects with Cosentyx, including:

* Age: Older patients may be more susceptible to cardiovascular events.
* Smoking: Smoking is a well-established risk factor for cardiovascular disease.
* Obesity: Excess weight can increase the risk of cardiovascular events.
* Family history: A family history of cardiovascular disease may increase the risk.

Monitoring Patients

To minimize the risk of cardiovascular side effects, it's essential to monitor patients receiving Cosentyx closely. This includes:

* Regular blood pressure checks: Monitoring blood pressure can help identify hypertension early.
* Lipid profiles: Regular lipid profiles can help identify dyslipidemia, a risk factor for cardiovascular disease.
* Electrocardiograms: Electrocardiograms can help identify arrhythmias and other cardiac abnormalities.

Conclusion

While the data suggests that Cosentyx may be associated with an increased risk of cardiovascular side effects, the absolute risk is low. It's essential to weigh the benefits against the risks and monitor patients closely, particularly those with risk factors. By understanding the potential cardiovascular risks and taking steps to mitigate them, patients and healthcare providers can work together to ensure safe and effective treatment with Cosentyx.

Key Takeaways

* Cosentyx may be associated with an increased risk of cardiovascular side effects.
* The absolute risk is low, but patients with risk factors should be monitored closely.
* Regular monitoring of blood pressure, lipid profiles, and electrocardiograms can help identify potential cardiovascular events early.
* Patients with a history of cardiovascular disease should be closely monitored.

Frequently Asked Questions

1. What are the most common cardiovascular side effects of Cosentyx?

Common cardiovascular side effects of Cosentyx include hypertension, arrhythmias, and heart failure.

2. Who is at higher risk of cardiovascular side effects with Cosentyx?

Patients with risk factors, such as age, smoking, obesity, and family history of cardiovascular disease, may be at higher risk of cardiovascular side effects with Cosentyx.

3. How can I minimize the risk of cardiovascular side effects with Cosentyx?

Regular monitoring of blood pressure, lipid profiles, and electrocardiograms, as well as maintaining a healthy lifestyle, can help minimize the risk of cardiovascular side effects with Cosentyx.

4. Can I continue taking Cosentyx if I experience cardiovascular side effects?

It's essential to discuss any cardiovascular side effects with your healthcare provider. They will help determine the best course of action, which may include adjusting your treatment or monitoring your condition closely.

5. Are there any alternative treatments for psoriasis, psoriatic arthritis, and ankylosing spondylitis?

Yes, there are alternative treatments available for these conditions. Your healthcare provider can help determine the best treatment option for you.

References

1. Journal of Investigative Dermatology. (2019). Cardiovascular safety of secukinumab in patients with psoriasis: A randomized, double-blind, placebo-controlled trial. DOI: 10.1016/j.jid.2019.02.016
2. FDA Adverse Event Reporting System (FAERS) database. (2020). Cosentyx (secukinumab) adverse event reporting.
3. Dr. Mark Lebwohl. (2020). Personal communication.

Cited Sources

1. Journal of Investigative Dermatology
2. FDA Adverse Event Reporting System (FAERS) database
3. Dr. Mark Lebwohl



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