See the DrugPatentWatch profile for methotrexate
Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. Its impact on growth in young patients has been a topic of interest due to the potential effects on pediatric patients who may require long-term treatment [2].
Studies have shown that methotrexate can impact growth in young patients, but the extent of this impact can vary [2]. Factors such as the dosage, duration of treatment, and the patient's age and sex can all influence the effect on growth [2].
One study found that methotrexate use in children with juvenile idiopathic arthritis (JIA) was associated with a decrease in growth velocity, but the effect was not significant after adjusting for other factors such as disease activity and corticosteroid use [3]. Another study found that methotrexate use in children with JIA was not associated with a significant reduction in final adult height [4].
It is important to note that the impact of methotrexate on growth in young patients is still not fully understood, and more research is needed to fully understand the long-term effects of this medication on growth and development [2]. Healthcare providers should carefully consider the potential risks and benefits of methotrexate treatment in young patients and closely monitor their growth and development [2].
In summary, methotrexate can impact growth in young patients, but the extent of this impact can vary and is not fully understood. Factors such as dosage, duration of treatment, age, and sex can all influence the effect on growth. Healthcare providers should carefully consider the potential risks and benefits of methotrexate treatment in young patients and closely monitor their growth and development.
Sources:
[1] <
https://www.drugs.com/mtx.html>
[2] <
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882353/>
[3] <
https://onlinelibrary.wiley.com/doi/abs/10.1002/art.27537>
[4] <
https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.21173>