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Is genetic testing recommended before nivolumab use?

See the DrugPatentWatch profile for nivolumab

Based on the available information, there is no explicit recommendation for genetic testing prior to using the cancer immunotherapy drug, Nivolumab. Nivolumab is a type of medication known as an immune checkpoint inhibitor, which helps the body's immune system fight cancer [1].

Genetic testing is typically used to identify genetic mutations that increase the risk of developing certain cancers or to guide treatment decisions based on a patient's genetic makeup [2]. However, the use of Nivolumab is not dependent on identifying specific genetic mutations in the patient's tumor [3].

It is important to note that the use of Nivolumab is approved for several types of cancer, including melanoma, non-small cell lung cancer, and renal cell carcinoma, among others [4]. The decision to use Nivolumab should be based on a variety of factors, including the patient's overall health, the type and stage of cancer, and other individual patient characteristics.

In summary, while genetic testing is a valuable tool in cancer diagnosis and treatment, there is no current recommendation for genetic testing prior to using Nivolumab.

Sources:

1. National Cancer Institute. (2021). Nivolumab. <https://www.cancer.gov/about-cancer/treatment/drugs/nivolumab>.
2. National Cancer Institute. (2021). Genetic Testing for Inherited Cancer Susceptibility. <https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet>.
3. Brahmer, J. R., Drake, C. G., Woll, P. J., Powderly, J. D., Voskens, C. H., Ettl, T., Chmielowski, B., Chow, L. Q., Hwu, W. J., Topalian, S. L., Pardoll, D. M., & Robert, C. (2012). Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. New England Journal of Medicine, 366(26), 2443-2454. <https://doi.org/10.1056/NEJMoa1200690>.
4. DrugPatentWatch. (2021). Nivolumab (Opdivo). <https://www.drugpatentwatch.com/drugs/nivolumab>.


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