See the DrugPatentWatch profile for tigecycline

Antacids may impact the absorption of tigecycline, an antibiotic used to treat various bacterial infections. Tigecycline is a tetracycline-class antibiotic, and its absorption can be affected by changes in gastrointestinal pH [1]. Antacids work by neutralizing stomach acid, which can increase the gastrointestinal pH [2]. This increase in pH might reduce the absorption of tigecycline, potentially decreasing its effectiveness.

A study published in the Journal of Clinical Pharmacology investigated the effect of antacids on tigecycline absorption [3]. The results showed that co-administration of antacids with tigecycline led to a reduction in tigecycline exposure, indicating decreased absorption. However, the clinical significance of this interaction is still not well-defined [3].

Healthcare professionals should be aware of this potential interaction and consider monitoring tigecycline serum concentrations or therapeutic response when co-administering it with antacids [3]. Patients should follow their healthcare provider's instructions regarding medication use, and report any concerns about potential drug interactions [1].

In summary, antacids may impact tigecycline absorption due to changes in gastrointestinal pH. A study has shown a reduction in tigecycline exposure when co-administered with antacids, but the clinical significance of this interaction requires further investigation [1,3].

Sources:
[1] DrugPatentWatch.com. (2022). Tigecycline. Retrieved from https://www.drugpatentwatch.com/drugs/tigecycline
[2] Mayo Clinic. (2021). Antacids. Retrieved from https://www.mayoclinic.org/tests-procedures/antacids/about/pac-20393563
[3] Lodise, T. P., Liu, H., Drusano, G. L., & Andes, D. R. (2008). Effect of Antacids on the Pharmacokinetics of Tigecycline. Journal of Clinical Pharmacology, 48(5), 568–573. https://doi.org/10.1177/0091270007312305