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Yes, Advil (ibuprofen) can interact with certain antidepressants, specifically those known as selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) [1].

These antidepressants include, but are not limited to, fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), venlafaxine (Effexor), and duloxetine (Cymbalta) [1].

The interaction between Advil and these antidepressants can result in increased levels of serotonin, a condition known as serotonin syndrome [1]. Symptoms of serotonin syndrome can range from mild (shivering, diarrhea) to severe (fever, seizures) [1].

It is important to consult with a healthcare provider or pharmacist before combining Advil with antidepressants [1]. They may recommend alternative medications or adjust the dosage to minimize the risk of interaction [1].

Sources:
[1] DrugPatentWatch.com. (2022). Ibuprofen Interactions with Antidepressants. Retrieved from https://www.drugpatentwatch.com/ibuprofen-interactions-with-antidepressants/