See the DrugPatentWatch profile for lipitor

Lipitor, a statin medication used to treat high cholesterol, does not directly decrease or increase the efficacy of other drugs [1]. However, it can interact with certain medications, which may affect their efficacy or increase the risk of side effects.

Lipitor is metabolized by the cytochrome P450 3A4 (CYP3A4) enzyme in the liver [1]. Drugs that inhibit or induce this enzyme can impact Lipitor's metabolism, leading to altered plasma concentrations and potential interactions.

For instance, drugs that inhibit CYP3A4, such as protease inhibitors, azole antifungals, and macrolide antibiotics, can increase Lipitor's plasma concentration, potentially enhancing its efficacy and the risk of side effects [1]. On the other hand, drugs that induce CYP3A4, like rifampin and some anticonvulsants, can decrease Lipitor's plasma concentration, which may reduce its efficacy [1].

It is essential to consult a healthcare professional or pharmacist for personalized advice on drug interactions, as the potential impact on drug efficacy and safety can vary depending on individual factors, such as dosage, duration of treatment, and the specific drugs involved [1].

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor Drug Interactions. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor/interactions