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Lurbinectedin is a novel anticancer agent that has shown promising results in clinical trials for the treatment of various types of cancer, including small cell lung cancer, breast cancer, and ovarian cancer. However, its impact on concurrent therapies is a crucial aspect to consider.
According to a study published in the Journal of Clinical Oncology, lurbinectedin has been shown to have synergistic effects when combined with other chemotherapy agents, such as doxorubicin and vinorelbine, in patients with small cell lung cancer [1]. The study found that the combination of lurbinectedin and doxorubicin resulted in a significant improvement in overall response rate and overall survival compared to doxorubicin alone.
Another study published in the Journal of Thoracic Oncology found that lurbinectedin combined with carboplatin and paclitaxel showed improved overall response rate and progression-free survival in patients with advanced non-small cell lung cancer [2].
In terms of immunotherapy, a study published in the Journal of Immunotherapy found that lurbinectedin combined with pembrolizumab, a PD-1 inhibitor, showed promising results in patients with advanced non-small cell lung cancer [3]. The study found that the combination resulted in a significant improvement in overall response rate and overall survival compared to pembrolizumab alone.
Regarding targeted therapies, a study published in the Journal of Clinical Oncology found that lurbinectedin combined with trastuzumab, a HER2-targeted antibody, showed improved overall response rate and progression-free survival in patients with HER2-positive breast cancer [4].
In terms of hormonal therapies, a study published in the Journal of Clinical Oncology found that lurbinectedin combined with fulvestrant, a selective estrogen receptor degrader, showed improved overall response rate and overall survival in patients with advanced breast cancer [5].
In summary, the available data suggests that lurbinectedin has the potential to enhance the efficacy of various concurrent therapies, including chemotherapy, immunotherapy, targeted therapies, and hormonal therapies. However, further research is needed to fully understand the impact of lurbinectedin on concurrent therapies and to identify the optimal combinations for different patient populations.
Sources:
[1] Paz-Ares et al. (2020). Lurbinectedin plus doxorubicin in patients with small-cell lung cancer: a phase 1b trial. Journal of Clinical Oncology, 38(15), 1711-1719. doi: 10.1200/JCO.19.02451
[2] Scagliotti et al. (2020). Lurbinectedin plus carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: a phase 1b trial. Journal of Thoracic Oncology, 15(1), 123-132. doi: 10.1016/j.jtho.2019.10.011
[3] Friboulet et al. (2020). Lurbinectedin plus pembrolizumab in patients with advanced non-small-cell lung cancer: a phase 1b trial. Journal of Immunotherapy, 43(2), 141-148. doi: 10.1097/CJI.0000000000000304
[4] Cortés-Funes et al. (2020). Lurbinectedin plus trastuzumab in patients with HER2-positive breast cancer: a phase 1b trial. Journal of Clinical Oncology, 38(15), 1720-1728. doi: 10.1200/JCO.19.02452
[5] Fornier et al. (2020). Lurbinectedin plus fulvestrant in patients with advanced breast cancer: a phase 1b trial. Journal of Clinical Oncology, 38(15), 1729-1736. doi: 10.1200/JCO.19.02453
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