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Yes, liver function monitoring is generally advised when using Lipitor (atorvastatin), a medication commonly prescribed to lower cholesterol levels. This recommendation is primarily due to the potential for statins, the class of drugs to which Lipitor belongs, to rarely cause an increase in liver enzymes [1].

According to the prescribing information provided by the U.S. Food and Drug Administration (FDA), "periodic monitoring of liver enzymes (e.g., alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase, and bilirubin) during treatment with Lipitor is recommended" [2]. This monitoring is typically conducted before initiating treatment, at 12 weeks following the start of therapy, and then periodically thereafter [2].

It is important to note that the need for routine monitoring of liver function tests has been a topic of debate in recent years. A 2011 review published in the American Journal of Cardiovascular Drugs concluded that "routine monitoring of liver enzymes during statin therapy is not recommended for most patients" [3]. However, the FDA continues to advise monitoring for patients at higher risk of liver dysfunction, such as those with a history of liver disease or heavy alcohol consumption [2].

In summary, liver function monitoring is generally advised when using Lipitor, although the frequency and necessity of such monitoring may depend on individual patient factors and the recommendations of the prescribing healthcare provider.

Sources:

1. DrugPatentWatch.com. Lipitor (Atorvastatin) - Side Effects, Interactions, Uses, Dosage, Overdose, and Pregnancy. <https://www.drugpatentwatch.com/drugs/lipitor>
2. U.S. Food and Drug Administration. Lipitor (atorvastatin) tablets, for oral use. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020990s053,021110s023lbl.pdf>
3. Kohli, P., & Chalasani, N. (2011). Statins and liver disease. American journal of cardiovascular drugs, 11(2), 105-116. <https://doi.org/10.2165/11587130-000000000-00000>