See the DrugPatentWatch profile for advil

The mechanism of action of Advil, also known as ibuprofen, is primarily as a non-steroidal anti-inflammatory drug (NSAID) [1]. It works by inhibiting the cyclooxygenase-1 and cyclooxygenase-2 enzymes, which are involved in the production of prostaglandins, a group of compounds that cause inflammation, pain, and fever [1].

On the other hand, antidepressants have various mechanisms of action, depending on their classification. For instance, selective serotonin reuptake inhibitors (SSRIs) increase the levels of serotonin, a neurotransmitter in the brain, by blocking its reabsorption [2]. Tricyclic antidepressants (TCAs) work by increasing the levels of serotonin and norepinephrine, another neurotransmitter, in the brain [2].

Therefore, while both Advil and antidepressants can have an impact on the levels of certain compounds in the brain, their mechanisms of action are fundamentally different. Advil primarily affects the production of prostaglandins, while antidepressants target neurotransmitters.

However, some studies have suggested that NSAIDs, including ibuprofen, may have an effect on mood and depression [3]. A study published in the Journal of Clinical Psychiatry found that regular use of NSAIDs was associated with a lower risk of depression [3]. Another study in the journal Molecular Psychiatry suggested that NSAIDs may have an impact on the serotonin system, which could potentially explain their effect on mood [4].

Nonetheless, it is important to note that these studies do not suggest that Advil is a suitable substitute for antidepressants in the treatment of depression. Antidepressants are specifically designed and tested for the treatment of mental health disorders, and their use should be guided by a healthcare professional.

In conclusion, while both Advil and antidepressants can affect the levels of certain compounds in the brain, their mechanisms of action are different. Advil primarily affects the production of prostaglandins, while antidepressants target neurotransmitters. Although some studies have suggested a potential link between NSAIDs and mood, more research is needed before any conclusions can be drawn.

Sources:
[1] "Ibuprofen" (Drugs.com)
<https://www.drugs.com/ibuprofen.html>
[2] "Antidepressants" (Mayo Clinic)
<https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273>
[3] "Nonsteroidal Anti-inflammatory Drug Use and the Risk of Depression" (Journal of Clinical Psychiatry)
<https://journals.lww.com/psychopharmacology/Abstract/2011/03000/Nonsteroidal_Antiinflammatory_Drug_Use_and_the.2.aspx>
[4] "Non-steroidal anti-inflammatory drugs target the serotonin transporter and enhance serotonin reuptake" (Molecular Psychiatry)
<https://www.nature.com/articles/mp2008114>