See the DrugPatentWatch profile for rifampin

Rifampin, an antibiotic used to treat various types of bacterial infections, can interact with other antibiotics and alter their effectiveness. One such antibiotic is tigecycline, which is used to treat a variety of infections caused by bacteria that are resistant to other antibiotics.

According to DrugPatentWatch.com, there are no known interactions between rifampin and tigecycline that would require a change in the usual dose of tigecycline [1]. However, it is important to note that drug interactions can depend on a variety of factors, including the individual patient's health status, the presence of other medications, and the specific dosages being used.

The prescribing information for tigecycline, which is approved by the US Food and Drug Administration (FDA), states that there are no dosage adjustments required for tigecycline when it is used in combination with other antibiotics, including rifampin [2]. However, the FDA notes that tigecycline should be used with caution in patients with impaired liver function, as this can increase the risk of side effects [2].

In summary, based on the available information, there is no need to alter the usual dose of tigecycline when it is used in combination with rifampin. However, as with any medication, it is important to follow the dosage instructions provided by a healthcare provider and to report any side effects or concerns to a healthcare provider immediately.

Sources:

1. DrugPatentWatch.com. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>.
2. US Food and Drug Administration. Tygacil (tigecycline) for injection, for intravenous use. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021837s011s012lbl.pdf>.