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There is no definitive scientific research indicating that Lipitor, a medication used to treat high cholesterol, directly affects the effectiveness of over-the-counter pain relievers during workouts.

Lipitor, a statin drug, works by blocking a substance your body needs to make cholesterol [1]. It's important to note that Lipitor and over-the-counter pain relievers like ibuprofen or acetaminophen target different systems within the body. Lipitor primarily affects the liver and cholesterol production, while pain relievers typically work by reducing inflammation or blocking pain signals in the brain [2][3].

However, it's always crucial to consult with a healthcare provider or pharmacist before combining any medications, including over-the-counter drugs, with prescription medications like Lipitor. This is because drug interactions can potentially occur, leading to unexpected side effects or changes in the effectiveness of either medication [4].

In summary, while there is no specific evidence that Lipitor affects the effectiveness of over-the-counter pain relievers during workouts, it's always best to consult with a healthcare professional before combining medications.

Sources:
[1] "Lipitor." Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Dec. 2020, www.mayoclinic.org/diseases-conditions/high-cholesterol/medications-treatments/lipitor/drg-20064116.
[2] "Lipitor." Drugs.com, www.drugs.com/lipitor.html.
[3] "Ibuprofen." Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Dec. 2020, www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/description/drg-20061881.
[4] "Medication Safety." American Heart Association, www.heart.org/en/healthy-living/fitness/why-is-physical-activity-so-important-for-health-and-wellbeing/medication-safety.