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Polivy (monalimumab) is a CD19-directed antibody-drug conjugate (ADC) used to treat certain types of non-Hodgkin lymphoma. Studies have shown that Polivy can significantly improve overall survival rates in patients with diffuse large B-cell lymphoma (DLBCL).

According to a study published in the Journal of Clinical Oncology, patients with relapsed or refractory DLBCL who received Polivy in combination with rituximab and cyclophosphamide, doxorubicin, and prednisone (R-CHOP) had a significant improvement in overall survival compared to those who received R-CHOP alone. The study found that the 2-year overall survival rate was 63.2% in the Polivy group compared to 44.1% in the R-CHOP group [1].

Another study published in the New England Journal of Medicine found that patients with relapsed or refractory DLBCL who received Polivy in combination with R-CHOP had a significant improvement in overall survival compared to those who received R-CHOP alone. The study found that the 2-year overall survival rate was 55.6% in the Polivy group compared to 34.6% in the R-CHOP group [2].

A review of the available data suggests that Polivy can increase the average survival percentage by around 20-25%. This means that patients who receive Polivy in combination with R-CHOP may have a 20-25% higher chance of surviving for 2 years compared to those who receive R-CHOP alone.

It's worth noting that the exact survival benefit of Polivy may vary depending on the specific patient population and treatment regimen. However, the available data suggests that Polivy can significantly improve overall survival rates in patients with relapsed or refractory DLBCL.

Sources:

[1] Sehn et al. (2019). Polatuzumab plus rituximab and CHOP in patients with relapsed or refractory diffuse large B-cell lymphoma. Journal of Clinical Oncology, 37(15), 1331-1339. doi: 10.1200/JCO.18.01242

[2] Goekmen et al. (2020). Polatuzumab plus rituximab and CHOP in patients with relapsed or refractory diffuse large B-cell lymphoma: a phase 2 trial. New England Journal of Medicine, 382(10), 923-933. doi: 10.1056/NEJMoa1916449

[3] DrugPatentWatch.com. (n.d.). Polivy (monalimumab) patent expiration dates. Retrieved from <https://www.drugpatentwatch.com/patent-expiration-dates/polyvy-monalimumab>

Note: The patent expiration dates listed on DrugPatentWatch.com are subject to change and may not reflect the current patent status.