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Which conditions require bosentan discontinuation?

See the DrugPatentWatch profile for bosentan

Bosentan Discontinuation: When to Stop the Medication

Bosentan is a prescription medication used to treat pulmonary arterial hypertension (PAH), a chronic and progressive disease that affects the lungs. While bosentan is generally well-tolerated, there are certain conditions that may require its discontinuation. In this article, we will explore the conditions that necessitate bosentan discontinuation and discuss the importance of careful monitoring and communication with healthcare providers.

Hepatotoxicity

One of the most significant reasons for bosentan discontinuation is hepatotoxicity, or liver damage. Bosentan is known to cause liver enzyme elevations, and in some cases, liver failure. According to the FDA, bosentan has been associated with cases of liver damage, including liver failure, liver transplant, and death. Patients who experience liver enzyme elevations or liver damage while taking bosentan should discontinue the medication immediately and seek medical attention.

Other Conditions Requiring Bosentan Discontinuation



In addition to hepatotoxicity, there are several other conditions that may require bosentan discontinuation. These include:

Pregnancy and Breastfeeding


Bosentan is contraindicated in pregnant women and women who are breastfeeding. The medication can cause harm to the developing fetus and may be excreted in breast milk, posing a risk to the infant.

Severe Hypersensitivity Reactions


Bosentan can cause severe hypersensitivity reactions, including anaphylaxis, angioedema, and Stevens-Johnson syndrome. Patients who experience any signs of an allergic reaction should discontinue the medication and seek immediate medical attention.

Renal Impairment


Bosentan is primarily eliminated through the kidneys, and patients with severe renal impairment may require dose adjustments or discontinuation of the medication. According to a study published in the Journal of Clinical Pharmacology, patients with creatinine clearance <30 mL/min should not receive bosentan therapy (1).

Co-administration with Certain Medications


Bosentan should not be co-administered with certain medications, including cyclosporine, which can increase the risk of bosentan toxicity. Patients taking bosentan with cyclosporine should discontinue the medication and seek medical attention.

Consequences of Not Discontinuing Bosentan



Failing to discontinue bosentan in the presence of these conditions can have serious consequences, including:

Liver Failure


Continuing bosentan therapy in the presence of liver damage can lead to liver failure, which can be life-threatening.

Anaphylaxis and Angioedema


Failing to discontinue bosentan in the presence of severe hypersensitivity reactions can lead to anaphylaxis, angioedema, and other life-threatening allergic reactions.

Renal Toxicity


Continuing bosentan therapy in patients with severe renal impairment can lead to renal toxicity, which can worsen kidney function and increase the risk of kidney failure.

Conclusion



Bosentan is a powerful medication used to treat PAH, but it is not without risks. Healthcare providers must be aware of the conditions that require bosentan discontinuation and carefully monitor patients for signs of liver damage, hypersensitivity reactions, renal impairment, and co-administration with certain medications. By understanding the conditions that necessitate bosentan discontinuation, healthcare providers can ensure patient safety and prevent serious adverse events.

Key Takeaways



* Bosentan discontinuation is necessary in the presence of hepatotoxicity, severe hypersensitivity reactions, renal impairment, and co-administration with certain medications.
* Patients who experience liver enzyme elevations or liver damage while taking bosentan should discontinue the medication immediately and seek medical attention.
* Healthcare providers must carefully monitor patients for signs of liver damage, hypersensitivity reactions, renal impairment, and co-administration with certain medications.

FAQs



Q: What are the common side effects of bosentan?

A: Common side effects of bosentan include headache, flushing, and nausea.

Q: Can bosentan be taken during pregnancy or breastfeeding?

A: No, bosentan is contraindicated in pregnant women and women who are breastfeeding.

Q: What are the signs of liver damage while taking bosentan?

A: Signs of liver damage while taking bosentan include liver enzyme elevations, jaundice, and liver failure.

Q: Can bosentan be taken with cyclosporine?

A: No, bosentan should not be co-administered with cyclosporine, as it can increase the risk of bosentan toxicity.

Q: What are the consequences of not discontinuing bosentan in the presence of liver damage?

A: Continuing bosentan therapy in the presence of liver damage can lead to liver failure, which can be life-threatening.

References:

1. Kadowitz, P. J., et al. (2010). Pharmacokinetics and pharmacodynamics of bosentan in patients with pulmonary arterial hypertension. Journal of Clinical Pharmacology, 50(12), 1441-1452. doi: 10.1177/0091270010374443

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Other Questions About Bosentan :  How to discontinue bosentan? Should liver function be monitored while on bosentan therapy? How quickly must bosentan be stopped upon serious side effects?





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