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Bosentan Discontinuation: When to Stop the Medication
Bosentan is a prescription medication used to treat pulmonary arterial hypertension (PAH), a chronic and progressive disease that affects the lungs. While bosentan is generally well-tolerated, there are certain conditions that may require its discontinuation. In this article, we will explore the conditions that necessitate bosentan discontinuation and discuss the importance of careful monitoring and communication with healthcare providers.
Hepatotoxicity
One of the most significant reasons for bosentan discontinuation is hepatotoxicity, or liver damage. Bosentan is known to cause liver enzyme elevations, and in some cases, liver failure. According to the FDA, bosentan has been associated with cases of liver damage, including liver failure, liver transplant, and death. Patients who experience liver enzyme elevations or liver damage while taking bosentan should discontinue the medication immediately and seek medical attention.
Bosentan is contraindicated in pregnant women and women who are breastfeeding. The medication can cause harm to the developing fetus and may be excreted in breast milk, posing a risk to the infant.
Bosentan can cause severe hypersensitivity reactions, including anaphylaxis, angioedema, and Stevens-Johnson syndrome. Patients who experience any signs of an allergic reaction should discontinue the medication and seek immediate medical attention.
Bosentan is primarily eliminated through the kidneys, and patients with severe renal impairment may require dose adjustments or discontinuation of the medication. According to a study published in the Journal of Clinical Pharmacology, patients with creatinine clearance <30 mL/min should not receive bosentan therapy (1).
Bosentan should not be co-administered with certain medications, including cyclosporine, which can increase the risk of bosentan toxicity. Patients taking bosentan with cyclosporine should discontinue the medication and seek medical attention.
Continuing bosentan therapy in the presence of liver damage can lead to liver failure, which can be life-threatening.
Failing to discontinue bosentan in the presence of severe hypersensitivity reactions can lead to anaphylaxis, angioedema, and other life-threatening allergic reactions.
Continuing bosentan therapy in patients with severe renal impairment can lead to renal toxicity, which can worsen kidney function and increase the risk of kidney failure.
Other Questions About Bosentan : How to discontinue bosentan? Should liver function be monitored while on bosentan therapy? How quickly must bosentan be stopped upon serious side effects?
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