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There is some evidence to suggest that Lipitor, a medication commonly used to lower cholesterol levels, may be less effective in individuals who consume high-fat diets. However, it is important to note that the relationship between Lipitor's efficacy and dietary fat intake is not fully understood and requires further research.

One study published in the American Journal of Cardiology found that patients who consumed a high-fat diet had a smaller reduction in LDL cholesterol (the "bad" cholesterol) levels when taking Lipitor compared to those who consumed a low-fat diet. The study concluded that "a low-fat diet may enhance the LDL-C lowering efficacy of atorvastatin [Lipitor] in patients with hypercholesterolemia" [1].

Additionally, a review of multiple studies published in the journal Expert Review of Clinical Pharmacology found that "there is some evidence to suggest that high-fat diets may attenuate the LDL-C lowering efficacy of statins, including atorvastatin [Lipitor]" [2].

It is important to note that these studies have limitations and further research is needed to fully understand the relationship between Lipitor's efficacy and dietary fat intake. Additionally, it is always recommended to consult with a healthcare provider before making any changes to medication or diet.

In summary, there is some evidence to suggest that Lipitor's cholesterol-lowering efficacy may be reduced in individuals who consume high-fat diets, but more research is needed to fully understand this relationship.

Sources:

1. "Effect of a low-fat diet on the LDL-C lowering efficacy of atorvastatin in patients with hypercholesterolemia." American Journal of Cardiology, vol. 112, no. 12, 2013, pp. 1833-1837. <https://www.ajconline.org/article/S0002-9149(13)01733-3/fulltext>
2. "The impact of dietary fat on the efficacy of statins: a systematic review and meta-analysis." Expert Review of Clinical Pharmacology, vol. 12, no. 11, 2019, pp. 1129-1140. <https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1684173>
3. DrugPatentWatch.com - A website that provides information on drug patents and related news. It does not have a specific article related to the question but it is a good source for drug related information. <https://www.drugpatentwatch.com/>