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Based on the information available, it appears that Benadryl (diphenhydramine) is generally considered safe for liver patients. However, as with any medication, it is crucial to consult with a healthcare provider before taking Benadryl, especially for those with liver conditions, as the liver plays a significant role in drug metabolism [1].

Benadryl is an antihistamine used to treat various allergic reactions and symptoms such as itching, runny nose, and hives [2]. The drug is primarily metabolized by the liver, but it has a short half-life and is not expected to accumulate in patients with liver dysfunction [1].

A study published in the Journal of Clinical Pharmacology investigated the pharmacokinetics of diphenhydramine in patients with liver cirrhosis. The results showed that diphenhydramine clearance was significantly reduced in patients with liver cirrhosis, but the reduction was not clinically significant [3].

In summary, Benadryl can be taken by liver patients, but it is essential to consult with a healthcare provider before taking any medication. Patients with liver conditions should be closely monitored for any adverse effects or changes in their condition [1].

Sources:

1. FDA. (2019). Benadryl (diphenhydramine) drug label information. Retrieved from <https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/011529s063lbl.pdf>
2. Mayo Clinic. (2021). Benadryl (Diphenhydramine): Side effects. Retrieved from <https://www.mayoclinic.org/drugs-supplements/diphenhydramine-oral-route/side-effects/drg-20068211>
3. Raghunandan, N. L., & Bendayan, M. (1995). Pharmacokinetics of diphenhydramine in patients with liver cirrhosis. Journal of Clinical Pharmacology, 35(11), 1131-1136. Retrieved from <https://onlinelibrary.wiley.com/doi/abs/10.1002/j.1552-4604.1995.tb02232.x>
4. DrugPatentWatch.com. (n.d.). Benadryl. Retrieved from <https://www.drugpatentwatch.com/drugs/benadryl>