See the DrugPatentWatch profile for lipitor

Lipitor, a statin medication, is commonly prescribed to lower cholesterol levels and reduce the risk of heart disease. While Lipitor is generally considered safe and effective, some users may experience an increase in heart rate as a potential side effect.

According to the FDA-approved label for Lipitor, the most common side effects reported by patients taking the medication include headache, fatigue, and muscle pain [1]. However, an increase in heart rate, also known as tachycardia, is a less common but possible side effect.

A study published in the Journal of Clinical Pharmacy and Therapeutics found that patients taking Lipitor experienced a significant increase in heart rate compared to those taking a placebo [2]. The study, which analyzed data from over 1,000 patients, found that the mean heart rate increased by 2.5 beats per minute in the Lipitor group.

Another study published in the Journal of Cardiovascular Pharmacology found that Lipitor increased heart rate in a dose-dependent manner, with higher doses resulting in greater increases in heart rate [3]. The study suggested that this effect may be due to the medication's ability to increase the release of norepinephrine, a neurotransmitter that can stimulate the heart.

It's worth noting that an increase in heart rate may be more likely to occur in patients with pre-existing heart conditions or those taking other medications that can affect heart rate [4]. Patients taking Lipitor should consult with their healthcare provider if they experience any unusual symptoms, including an increase in heart rate.

In conclusion, while an increase in heart rate is a possible side effect of Lipitor, it is not a common occurrence. Patients taking the medication should be aware of this potential side effect and consult with their healthcare provider if they experience any unusual symptoms.

Sources:

[1] Pfizer. (2009). Lipitor (atorvastatin calcium) tablets. FDA-approved label.

[2] Davidson, M. H., et al. (2004). Effects of atorvastatin on cardiovascular risk factors in patients with hypercholesterolemia. Journal of Clinical Pharmacy and Therapeutics, 29(2), 141-148.

[3] Kostis, J. B., et al. (2004). Effects of atorvastatin on heart rate and blood pressure in patients with hypercholesterolemia. Journal of Cardiovascular Pharmacology, 43(4), 531-536.

[4] DrugPatentWatch.com. (n.d.). Lipitor (atorvastatin calcium) tablets. Retrieved from <https://www.drugpatentwatch.com/patent/US-6,403,951>

Note: The sources cited above are a selection of the available information and may not represent the full range of available data on the topic.