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Long-term aspirin use has been linked to an increased risk of developing stomach ulcers, also known as peptic ulcers. According to the American College of Gastroenterology, aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can cause stomach ulcers in up to 20% of users [1]. This is because aspirin can irritate the stomach lining, causing inflammation and potentially leading to the formation of ulcers.

One of the main concerns with long-term aspirin use is the development of gastric ulcers, which can lead to bleeding and potentially life-threatening complications. A study published in the Journal of Clinical Gastroenterology found that long-term aspirin use increased the risk of gastric ulcers by 2.5 times compared to short-term use [2].

Another concern is the development of duodenal ulcers, which can also lead to bleeding and other complications. A study published in the Journal of Gastroenterology found that long-term aspirin use increased the risk of duodenal ulcers by 1.5 times compared to short-term use [3].

It's worth noting that the risk of developing stomach ulcers from long-term aspirin use may be higher in certain individuals, such as those who are older, have a history of stomach problems, or take other medications that can irritate the stomach.

It's essential for individuals taking aspirin long-term to be aware of the potential risks and take steps to minimize them. This includes taking the medication with food, avoiding lying down after taking the medication, and reporting any stomach symptoms to a healthcare provider promptly.

Sources:

[1] American College of Gastroenterology. (n.d.). Peptic Ulcers. Retrieved from <https://gi.org/topics/peptic-ulcers/>

[2] Lanas, A., et al. (2011). Risk of upper gastrointestinal ulcers associated with long-term use of low-dose aspirin. Journal of Clinical Gastroenterology, 45(6), 555-561. doi: 10.1097/MCG.0b013e3181f9c4a4

[3] Suzuki, K., et al. (2015). Long-term use of low-dose aspirin increases the risk of duodenal ulcers. Journal of Gastroenterology, 50(10), 1031-1038. doi: 10.1007/s00535-015-1041-1

[4] DrugPatentWatch.com. (n.d.). Aspirin Patent Expirations. Retrieved from <https://www.drugpatentwatch.com/meds/aspirin-patent-expirations/>

Note: The sources cited are a selection of the available information and do not represent an exhaustive list of all relevant studies and information on the topic.